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  • Postdoc
  • 36 hours per week
  • Duration 2 years
  • Closing 23 February 2020

Your position
The virtual institute ‘Regenerative Medicine Crossing Borders (RegMedXB)’, composed of universities, health foundations, governments and private companies in the Netherlands and Belgium is looking for two postdocs to contribute to developing innovating strategies to regenerate the heart. Are you the experienced researcher we are looking for ?

What you do
The program aim is to develop a system of ex vivo organ perfusion that allows to repair the human heart ex vivo and return it to the patient after one week of mechanical support and prolonged narcosis. Your project will focus on the development of approaches to stimulate cardiomyocyte proliferation using in vitro and ex vivo models to maintain and restore contractility of the damaged heart and thereby minimize or prevent disease progression. Although the myocardium contains both cardiomyocytes and non-cardiomyocytes (e.g. endothelial cells and fibroblasts) nicely aligned in a network of extracellular matrix, the first focus of this project is to use different approaches to induce proliferation (small molecules, modified RNA/DNA or via gene therapy). In particular, the project will aim to identify the optimal protocol to modify the diseased myocardium. Ultimately, a recently developed ex vivo heart culture system, as well as other human cardiac tissue culture models, and in vivo disease models, provide an excellent opportunity to monitor early functional improvement and/or side effects of cell cycle modulation and genetic treatment.

What we ask
You hold a PhD degree in medicine, biomedical sciences or a similar area. You have a background in stem cell and/or molecular biology and affinity with medical applications. You have experience with (cardiac) cell and tissue culture, with emphasis on disease modelling. Furthermore, you have the ability to contribute to and initiate multidisciplinary collaborations. You also possess excellent written and oral communication skills in English, are results driven and have a proactive attitude.

Your workplace
You will be part of the cardiovascular cell biology group of the Department of Cell and Chemical Biology (CCB). You will work in a multidisciplinary team that focusses on cardiovascular repair, and in close collaboration with the Department of Cardiology. CCB and Cardiology are equipped with state of the art facilities for research. We will collaborate intensively with our partners in the RegMedXB Cardiac Moonshot consortium and with other research groups within the LUMC Regenerative Medicine profile.


Marie-José Goumans, professor, Department of Cell and Chemical Biology via +31(0)71 526 92 77

Apply online

No agencies please

Key words: Vacancy, Research, Postdoc, Regenerative Medicine, Leiden, Zuid-Holland