“Geriatric anti-donor T-cell activity and development of alloreactive long-term hypo-responsive T cell function (GANDALF)”.

  • 41.17.18.TD
  • 36 hours per week

Job description
We are searching for an enthusiastic PhD student to work on a Dutch Kidney Foundation awarded entitled: “Geriatric anti-donor T-cell activity and development of alloreactive long-term hypo-responsive T cell function (GANDALF); Post-transplant development of anti-donor-specific hypo-responsiveness; Lessons to be learned from older kidney transplant recipients”.

Long after kidney transplantation, T-cell reactivity towards the donor kidney declines, also referred to as donor-specific hypo-responsiveness (DSH). Little is known with respect to how and when this occurs. Older kidney transplant recipients seem to develop DSH earlier and faster. The kidney transplant recipient might then be able to receive/do well with less immunosuppression. In this project, we will unravel the mechanism(s) of developing DSH in relation to the age of the kidney transplant recipient. The obtained knowledge may guide the use of immunosuppression after transplantation leading to personalized medicine.

Work environment
Erasmus MC stands for a healthy population and excellence in healthcare. By conducting groundbreaking work, we aim to push boundaries through leading the way in research, education and healthcare. We have access to the latest equipment and techniques in a state-of-the-art environment.The Erasmus MC is one of the largest transplant centers in Europe.

The section Nephrology and Transplantation within the Department of Internal Medicine is involved in kidney transplant patient care and research & education. The PhD student will be based in the Transplantation Laboratory of Internal Medicine where 20 employees such as  postdocs, technicians, PhD and undergraduate students are working. Research within the Transplantation Laboratory is primarily of translational nature and can be dissected into two research lines being Transplantation Immunology and Tissue Repair & Cell Therapy. In addition, we are also involved in Diagnostics in the setting of solid organ transplantation

Qualifications and skills
Suitable candidates have a Master’s degree in Biology, Biomedical Sciences or a comparable subject and have affinity with the described research. Experience in flow cytometry, cell culture and molecular biology and affinity with bio-informatics are an advantage. Candidates should have good social competences, good English language skills and should be able to work alone as well as in a multidisciplinary team.

Being able to present a certificate of good conduct, a valid proof of identity, diploma’s and/ or relevant registration such as BIG/ RGS are conditions for the appointment.

Terms of employment
The candidate will receive a temporary position for 4 years. The gross monthly salary is € 2.279,- in the 1st year and increases to € 2.919,- in the 4th year (scale OIO). The terms of employment are according to the Collective Bargaining Agreement for Dutch University Medical Centers (CAO UMC).

Information and application
For more information about this position, please contact Nicolle Litjens, Immunologist, phone number: +31 (0)10 703 54 18. For queries regarding your application, please contact Jerry Chandansingh, recruiter, phone number: +31 (0)10 704 49 83.

If you are excited by the thought of this position and would like to apply, please do so by using the application form with this link. Application deadline 21-11-2018

No agencies please.

Keywords: Vacancy, Research, WO, Master, Life Sciences, Biology, Biomedical Sciences, Rotterdam, Zuid-Holland.