PhD candidate to study and engineer plant specialized metabolite biosynthesis | 1,0 fte

This PhD projects explores new bioactive metabolites and aims to study their biosynthesis to create engineering tools for their production.

The Faculty of Science / the Institute for Biology is looking for a

PhD candidate to study and engineer plant specialized metabolite biosynthesis

• WO / master
• 1,0 fte
• from € 2.972,- to € 3.670,-
• Closing date: December 9th 2024

Key responsibilities

The chemical diversity of plants, which produce hundreds of thousands of specialized metabolites (i.e. natural products), has been a rich resource for medicine and other valuable compounds. Understanding the biosynthesis of valuable metabolite on a molecular level enables us to advance their engineering and improve cultivated plant systems. This PhD projects explores new bioactive metabolites and aims to study their biosynthesis to create engineering tools for their production.

Your key responsibilities include:

• Plan and conduct research activities
• Present your work and take part in research discussions, write thesis and manuscripts
• Co-supervise BSc and MSc students
• Contribute to lab organization and teaching

Selection Criteria

• Master’s degree in biology, biochemistry or related disciplines
• Experience and skills in molecular biology, bioinformatics and analytical techniques, specifically LC-MS, GNPS, transcriptomics, differential gene expression, cloning, yeast engineering
• Experience in working with plant specialized metabolites, glycosylation of small molecules, protein biochemistry and microscopy are an advantage
• Confident in the use of analytical software such as MZmine, R, Geneious
• Possess a strong curiosity with an interest in plant sciences
• Highly motivated to obtain a PhD degree and understand the commitment
• Enthusiastic person who is keen on gaining new knowledge and learning new technics, enjoys doing science and who is not afraid of a challenge and can be resilient and tolerate stress
• Great organization and time management skills.
• Capable to structure and plan work independently as well as under supervision and within a research team.
• Great English skills (spoken and written).

Research at our faculty

The Faculty of Science is a world-class faculty where staff and students work together in a dynamic international environment. It is a faculty where personal and academic development are top priorities. Our people are committed to expand fundamental knowledge by curiosity and to look beyond the borders of their own discipline; their aim is to benefit science, and to make a contribution to addressing the major societal challenges of the future.

The research carried out at the Faculty of Science is very diverse, ranging from mathematics, information science, astronomy, physics, chemistry and bio-pharmaceutical sciences to biology and environmental sciences. The research activities are organised in eight institutes. These institutes offer eight bachelor’s and twelve master’s programmes. The faculty has grown strongly in recent years and now has more than 2300 staff and almost 5000 students. We are located at the heart of Leiden’s Bio Science Park, one of Europe’s biggest science parks, where university and business life come together.
For more information, see https://www.universiteitleiden.nl/en/science and https://workingat.leiden.edu/

The Institute for Biology

The research within the Institute of Biology Leiden (IBL) aims to work on the science base of biodiversity and health, which is reflected in our leading principle Harnessing Biodiversity for Health. We perform innovative curiosity-driven research to answer fundamental questions, and solutions-driven research to help solving major societal challenges. The latter include protecting nature’s biodiversity, creating sustainable biotechnology and agriculture and increasing good health. Our research focuses on four Research Themes: Bioactive Molecules, Host-Microbe Interactions, Development & Disease and Evolution & Biodiversity. Located in a thriving scientific environment with our Faculty of Sciences, Naturalis Biodiversity Centre, the Leiden University Medical Centre and the Leiden Bioscience Park, IBL offers an exciting, internationally oriented and inclusive place to work and study.

Terms and conditions

• We offer a full-time 1 year term position for initially one year. After a positive evaluation of the progress of the thesis, personal capabilities and compatibility the appointment will be extended by a further three years. Salary range from €2.972,-- to € 3.670,-- gross per month (pay scale P in accordance with the Collective Labour Agreement for Dutch Universities).
• Leiden University offers an attractive benefits package with additional holiday (8%) and end-of-year bonuses (8.3 %), training and career development and sabbatical leave. Our individual choices model gives you some freedom to assemble your own set of terms and conditions. Candidates from outside the Netherlands may be eligible for a substantial tax break.
• All our PhD students are embedded in the Leiden University Graduate School of Science www.graduateschools.leidenuniv.nl. Our graduate school offers several PhD training courses at three levels: professional courses, skills training and personal effectiveness. In addition, advanced courses to deepen scientific knowledge are offered by the research school.

Leiden University is strongly committed to diversity within its community and especially welcomes applications from members of underrepresented groups.